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Buy Xartemis XR( oxycodone hydrochloride and acetaminophen)

$2.40 $1.40

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Description

Buy Xartemis XR( oxycodone hydrochloride and acetaminophen)

 

Buy Xartemis XR( oxycodone hydrochloride and acetaminophen) Do not break, chew, crush, cut, dissolve or split the tablets. Breaking, chewing, crushing, cutting, dissolving or splitting Xartemis XR tablets will result in uncontrolled delivery of oxycodone and can lead to overdose or death. Buy oxycodone HCL online

Clinical Results

FDA Approval
The FDA approval of Xartemis XR was based on a randomized, double blind, placebo controlled, parallel arm multi dose study comparing Xartemis XR and placebo in 303 subjects with acute pain following a unilateral first metatarsal bunionectomy. All subjects met the criteria of pain intensity >4 on a 0 to 10 numerical pain rating scale and received a fixed-dose of 2 tablets of Xartemis XR (7.5 mg oxycodone hydrochloride and 325 mg acetaminophen) tablets or placebo every 12 hours over 48 hours.  Mean baseline pain intensity scores were 6.2 in the Xartemis XR group and 6.0 in the placebo group. Approximately 85% of the 150 subjects treated with Xartemis XR and 98% of the 153 subjects treated with placebo took rescue medication at least once for pain management during the 48 hours after the first dose. The median time to onset of pain relief was less than one hour for Xartemis XR. The primary endpoint was the summed pain intensity difference (change in pain from baseline) over 48 hours (SPID48), which demonstrated improvement in pain from baseline for the Xartemis XR treatment group compared to placebo. Xartemisxr

Side Effects

  • nausea
  • dizziness
  • headache
  • vomiting
  • constipation
  • somnolence

Mechanism of Action

Xartemis is an extended release formulation of oxycodone hydrochloride and acetaminophen. Oxycodone HCl is an opioid agonist and is relatively selective for the mu receptor, although it can interact with other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all opioid agonists, there is no ceiling effect to analgesia. Acetaminophen is a non-opioid, non-salicylate analgesic, and antipyretic. The site and mechanism for the analgesic effect of acetaminophen has not been determined. The antipyretic effect of acetaminophen is accomplished through the inhibition of endogenous pyrogen action on the   centers.

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