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Methadone

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Methadone

Methadone synthetic opiate whose analgesic properties were first discovered in the 1940s, was initially used to manage chronic pain. In the early 1960s, it was discovered that when taken daily at an appropriate maintenance dose, methadone benefited patients experiencing withdrawal from other opioids, including morphine and heroin.nt with methadone is only one part of the recovery process. MMT also includes counseling, lifestyle modification, and other supportive services. It is important for patients to understand that constant personal reflection, ongoing counseling, and an awareness of the ramifications of continued use of other drugs all play a role in the success or failure of recovery from addiction.Buy  Methadone is not indicated for the treatment of addiction to drugs in other classes or to other substances.

Like the opioids, methadone acts on receptors in the brain that control pain and mood. Since methadone is metabolized in the liver through cytochrome P (CYP) enzymes (including CYP450, CYP3A4, CYP2C8, and CYP2D66), some care is warranted regarding use of other medications that may inhibit or induce substances in this enzyme class.7 (See table.7-10) Patients who take other medications that are influenced by CYP enzymes should be monitored for cross-reactions and may require medication adjustment. A thorough history of medication use and close monitoring of potential medication combinations are warranted.

 

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